Ethyl Acetate → 2-(4-Amino-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl ester

HRID 1678653ノート

反応式

HRID 1678653 の反応式
[CH2:1]([O:3][C:4](=[O:19])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([F:18])[CH:10]=1)([CH3:7])[CH3:6])[CH3:2].[H][H].C(OCC)(=O)C>[Pd].C(O)C>[CH2:1]([O:3][C:4](=[O:19])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([F:18])[CH:10]=1)([CH3:7])[CH3:6])[CH3:2]

参加物

6

反応物 3

HCID 8857Ethyl AcetateHCID 671311902-(3-Fluoro-4-nitro-phenoxy)-2-methyl-propionic acid ethyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 671309762-(4-Amino-3-fluoro-phenoxy)-2-methyl-propionic acid ethyl ester収率 127.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

10% Palladium on carbon (200 mg) was added to a solution of 2-(3-fluoro-4-nitro-phenoxy)-2-methyl-propionic acid ethyl ester (1.15 g, 4 mmol) in ethanol (20 ml). The suspension was hydrogenated at a hydrogen gas pressure of 1.7 bar for 8 h at ambient temperature. Ethyl acetate was added (100 ml), the solid was filtered off and the filtrate was brought to dryness under reduced pressure to give the title compound (1.23 g, quant.) which was used in the next step without further purification.

後処理

  1. filtrationthe solid was filtered off

出典と根拠

ORDレコード
ord-be4c83477416454680c77d2c89bb4fd7
出典データセット
uspto-grants-2011_08
特許番号
US08008505B2

反応ノート

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