HCID 86642727、化合物 → HCID 136388709、化合物
反応式
C([O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[N:14][N:15]2[CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[CH3:24][N:25]([CH3:30])[C:26](=[O:29])[CH2:27][CH3:28]>C1COCC1>[OH:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[N:14][N:15]2[CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)=[CH:11][CH:10]=1.[CH3:24][N:25]([CH3:30])[C:26](=[O:29])[CH2:27][CH3:28]参加物
3
実験手順
5% palladium on carbon-STD-type-50% wet with water (224 mg; manufactured by N.E. Chemcat Corp.), and a THF solution of 3-(6-(benzyloxy)-1-(tetrahydro-2H-pyran-2-yl)-indazole-N,N-dimethylpropanamide that can be produced by the method described in Reference Example 51 or the like [6.3 mL; prepared by dissolving 3-(6-(benzyloxy)-1-(tetrahydro-2H-pyran-2-yl)-indazole-N,N-dimethylpropanamide (596 mg) in dehydrated THF (7.3 mL)) were mixed, and the reaction system was purged with hydrogen. Under a hydrogen atmosphere, the reaction solution was stirred overnight at room temperature. The reaction solution was purged with nitrogen, and then was filtered. The solvent was evaporated under reduced pressure from the filtrate, and thus the title compound (383 mg) was obtained.