Hydrochloric Acid → 4-[3-(Hydroxymethyl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]benzaldehyde

HRID 1678778ノート

反応式

HRID 1678778 の反応式
[O:1]1CCO[CH:2]1[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:20][C:19]3[C:18]4=[N:28][N:29]=[C:30]([CH2:31][OH:32])[N:17]4[CH:16]=[CH:15][C:14]=3[N:13]=2)=[CH:8][CH:7]=1.Cl>C1COCC1.C(OCC)(=O)C>[OH:32][CH2:31][C:30]1[N:17]2[C:18]([C:19]3[CH:20]=[C:21]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[C:12]([C:9]4[CH:10]=[CH:11][C:6]([CH:2]=[O:1])=[CH:7][CH:8]=4)=[N:13][C:14]=3[CH:15]=[CH:16]2)=[N:28][N:29]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 59472958{8-[4-(1,3-Dioxolan-2-yl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-3-yl}methanol

生成物 1

HCID 594728804-[3-(Hydroxymethyl)-9-phenyl[1,2,4]triazolo[3,4-f]-1,6-naphthyridin-8-yl]benzaldehyde

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a suspension of 14-1 (2.1 g, 4.9 mMol) in THF (50 mL) was added 1N HCl (50 mL). After stirring at room temperature for 30 minutes, the reaction was diluted with ethyl acetate and washed twice with water, followed by brine. The organic layer was dried with MgSO4 and Na2SO4, filtered and concentrated in vacuo to yield 14-2 as a red solid. Mass (M+1) calculated: 381.1346 observed: 381.1346.

後処理

  1. washwashed twice with water
  2. dry with materialThe organic layer was dried with MgSO4 and Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1264493ef6fb4777b70ebaa459783547
出典データセット
uspto-grants-2011_08
特許番号
US08008317B2

反応ノート

読み込み中…