Hydrochloric Acid → 1-Propyl-1H-imidazole-4-carboxylic acid
反応式
[CH2:1]([N:4]1[CH:8]=[C:7]([C:9]([O:11]C)=[O:10])[N:6]=[CH:5]1)[CH2:2][CH3:3].[Li+].[OH-].Cl>CO>[CH2:1]([N:4]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[N:6]=[CH:5]1)[CH2:2][CH3:3]参加物
5
反応条件
- 温度
- 80 °C
実験手順
To a solution of 25-2 (0.6 g, 3.6 mmol) in anhydrous MeOH (2 ml) was added 3N LiOH (2.6 ml, 7.9 mmol). The reaction mixture was heated at 80° C. for 1 h. The heat was reduced and the mixture was stirred at 40° C. overnight. The reaction was then neutralized with 12N HCl and subsequently concentrated in vacuo. The residue was dried azeotropically with toluene to afford the desired product 25-3 as a solid. MS calculated M+H, 155.2. Found 155.1
後処理
- concentrationsubsequently concentrated in vacuo
- dry with materialThe residue was dried azeotropically with toluene
出典と根拠
- ORDレコード
- ord-02b8e885e986433cb45f3666221e847b
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US08008317B2
反応ノート
読み込み中…