Phenol → Phenyl hexanoate

HRID 1678977ノート

反応式

HRID 1678977 の反応式
[C:1](Cl)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[C:9]1([OH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>N1C=CC=CC=1>[C:1]([O:15][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

参加物

4

反応物 2

HCID 996PhenolHCID 67340Hexanoyl chloride

生成物 1

HCID 522678Phenyl hexanoate収率 94.7%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

30 ml (0.22 mole) of hexanoyl chloride were added dropwise over 30 minutes with stirring and cooling on an ice bath to a solution of 18.8 g (0.2 mole) of phenol in 80 ml of anhydrous pyridine and then the reaction mixture stood at room temperature for 3 hours and was poured into ice water. The mixture was extracted with ether and the ether extracts were washed with water, dilute hydrochloric acid and with water, dried over magnesium sulfate and evaporated to dryness to obtain 36.4 g of phenyl hexanoate as a yellow oil.

後処理

  1. extractionThe mixture was extracted with ether
  2. washthe ether extracts were washed with water, dilute hydrochloric acid and with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-f49c262856cb4177bd41e988fbf8f852
出典データセット
uspto-grants-1978_03
特許番号
US04078078

反応ノート

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