Thionyl Chloride → 1-(2-Chloro-4-phenylbutyl)imidazole hydrochloride

HRID 1678985ノート

反応式

HRID 1678985 の反応式
O[CH:2]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1.S(Cl)([Cl:19])=O>ClCCl>[ClH:19].[Cl:19][CH:2]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 134573551-(2-Hydroxy-4-phenylbutyl)imidazole

生成物 1

HCID 203652681-(2-Chloro-4-phenylbutyl)imidazole hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 1.00 g. of 1-(2-hydroxy-4-phenylbutyl) imidazole in 40 ml. of dichloromethane was treated with 1 ml. of thionyl chloride with stirring and the solution heated to gentle reflux for one hour. Evaporation to dryness afforded 1-(2-chloro-4-phenylbutyl) imidazole hydrochloride as a white solid.

後処理

  1. temperaturethe solution heated
  2. temperatureto gentle reflux for one hour
  3. customEvaporation to dryness

出典と根拠

ORDレコード
ord-34751d25808c422b92aac66fa3792dfd
出典データセット
uspto-grants-1978_03
特許番号
US04078071

反応ノート

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