Water → N-acetyl-3-phenylindoline

HRID 1679274ノート

反応式

HRID 1679274 の反応式
[C:1]1([CH:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[OH-].[Na+].[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:19]([N:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8]1)(=[O:21])[CH3:20]

参加物

5

反応物 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 109323533-phenyl-2,3-dihydro-1H-indole

生成物 1

HCID 15428722N-acetyl-3-phenylindoline

実験手順

1.0 G of 3-phenylindoline was dissolved in 10 ml of acetic anhydride at room temperature. After 10 minutes, the reaction mixture was poured into 100 ml of water, slightly basified with aqueous sodium hydroxide and extracted with methylene chloride. After removal of the methylenechloride, the residue was recrystallized from cyclohexane to give 1.15 g of the desired N-acetyl-3-phenylindoline which was found to have a 106°-7° C.

後処理

  1. extractionextracted with methylene chloride
  2. customAfter removal of the methylenechloride
  3. customthe residue was recrystallized from cyclohexane

出典と根拠

ORDレコード
ord-2d6b61be50b84b52b1ac368ad7d40746
出典データセット
uspto-grants-1978_03
特許番号
US04080330

反応ノート

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