Sodium Hydroxide → HCID 23695280、化合物

HRID 1679507ノート

反応式

HRID 1679507 の反応式
[Cl:1][CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]([CH3:25])([CH3:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:11][CH:10]=1)[C:3]([O:5]CC)=[O:4].[OH-].[Na+:27]>C(O)C.O>[Cl:1][CH:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]([CH3:25])([CH3:24])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:11][CH:10]=1)[C:3]([O-:5])=[O:4].[Na+:27]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 194150Ethyl alpha-chloro-4-(2-methyl-2-phenylpropoxy)benzenepropanoate

生成物 1

HCID 23695280HCID 23695280、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

In 15 ml of ethanol is dissolved 3.6 g of ethyl 2-chloro-3-[4-(2,2-dimethyl-2-phenylethyloxy)phenyl]propionate, and under cooling with ice and stirring, a solution of 0.35 sodium hydroxide in 3.5 ml water is added. The mixture is kept under the same condition for 30 minutes, after which the solution is concentrated to dryness. The residue is dissolved in 10 ml of water, the solution is washed three times with ether, and then the solution is concentrated to dryness. The procedure yields 2.6 g of sodium 2-chloro-3-[4-(2,2-dimethyl-2-phenylethyloxy)-phenyl]propionate, as white amorphous substance.

後処理

  1. temperatureunder cooling with ice
  2. concentrationafter which the solution is concentrated to dryness
  3. dissolutionThe residue is dissolved in 10 ml of water
  4. washthe solution is washed three times with ether
  5. concentrationthe solution is concentrated to dryness

出典と根拠

ORDレコード
ord-c61f1f2068714e40af99166812fd33ab
出典データセット
uspto-grants-1978_03
特許番号
US04080505

反応ノート

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