Resorcinol → 2-Ethyl-4-(3-trifluoromethylphenyl)-7-hydroxy-2-methyl-2H-chromene

HRID 1679524

反応式

HRID 1679524 の反応式
[CH2:1]([C:3]1([CH3:15])[CH2:12][C:11](=O)[C:10]2[C:5](=[CH:6][C:7]([OH:14])=[CH:8][CH:9]=2)[O:4]1)[CH3:2].C1(C=CC=C(O)C=1)O.B(F)(F)F.CCOCC.C1C=CC2OCCC(=O)C=2C=1.[F:44][C:45]([F:55])([F:54])[C:46]1[CH:47]=[C:48]([Mg]Br)[CH:49]=[CH:50][CH:51]=1>>[CH2:1]([C:3]1([CH3:15])[CH:12]=[C:11]([C:50]2[CH:49]=[CH:48][CH:47]=[C:46]([C:45]([F:55])([F:54])[F:44])[CH:51]=2)[C:10]2[C:5](=[CH:6][C:7]([OH:14])=[CH:8][CH:9]=2)[O:4]1)[CH3:2]

参加物

6

反応物 5

HCID 5054ResorcinolHCID 8000Boron trifluoride etherateHCID 68110ChromanoneHCID 205705082-Ethyl-7-hydroxy-2-methyl-4-chromanoneHCID 178506173HCID 178506173、化合物

生成物 1

HCID 205705652-Ethyl-4-(3-trifluoromethylphenyl)-7-hydroxy-2-methyl-2H-chromene

実験手順

2-Ethyl-7-hydroxy-2-methyl-4-chromanone, m.p. 109°-110.5° C, was prepared by condensing resorcinol with 3-methyl-2-pentanoic acid in the presence of boron trifluoride diethyl etherate. Reaction of the chromanone with 3-trifluoromethylphenyl magnesium bromide as described in Preparation 5 gave the title chromene as a golden yellow oil.

後処理

  1. customas described in Preparation 5

出典と根拠

ORDレコード
ord-b21c6b4324f140f2b222c7fef619efd4
出典データセット
uspto-grants-1978_03
特許番号
US04080335

関連ノート

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