Trifluoroacetic acid → HCID 88813774、化合物

反応式

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH3:11])=[O:9])=[O:5])[CH3:3].[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[CH3:11][O:10][C:8](=[O:9])[CH2:7][NH:6][C:4](=[O:5])[C@H:2]([CH3:3])[NH2:1]

参加物

反応物 2

HCID 6422Trifluoroacetic acid

HCID 14158799HCID 14158799、化合物

生成物 1

HCID 88813774HCID 88813774、化合物

反応条件

温度: 0 °C

実験手順

Boc-Ala-Gly-OMe [10 g, 45 mmoles, described by H. U. Immer et al., Helv. Chim. Acta, 57, 730 (1974)] is dissolved in cold (ice bath) trifluoroacetic acid (100 ml). The solution is stirred for 1 hr at 0° C and the solvent evaporated. The residue is dissolved in methanol, added to diethyl ether and the precipitate collected to yield the title compound.

後処理

customthe solvent evaporated
dissolutionThe residue is dissolved in methanol
additionadded to diethyl ether
customthe precipitate collected

出典と根拠

ORDレコード: ord-70b1e0cc27e8411d82ffa2ede26c0f25
出典データセット: uspto-grants-1978_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04081530

反応ノート

読み込み中…

参加物