m-Chloroperbenzoic acid → 2-Methyl-5-nitropyridine N-oxide

HRID 1680460ノート

反応式

HRID 1680460 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH3:10])=[N:8][CH:9]=1)([O-:3])=[O:2].ClC1C=CC=C(C(OO)=[O:19])C=1>C(Cl)Cl>[N+:1]([C:4]1[CH:9]=[N+:8]([O-:19])[C:7]([CH3:10])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 27945522-Methyl-5-nitropyridine

生成物 1

HCID 127053092-Methyl-5-nitropyridine N-oxide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2.5 g of 5-nitro-2-picoline are dissolved in 60 ml of methylene chloride and 4.05 g (20 m mole) of 85% m-chloroperbenzoic acid are added while stirring at room temperature. Stirring is continued overnight and the mixture is washed twice with aqueous sodium bicarbonate and then with water. It is dried, evaporated and the residue crystallized from acetonitrile, to yield the 5-nitro-2-picoline-N-oxide melting at 149°-153°.

後処理

  1. stirringStirring
  2. washthe mixture is washed twice with aqueous sodium bicarbonate
  3. customIt is dried
  4. customevaporated
  5. customthe residue crystallized from acetonitrile

出典と根拠

ORDレコード
ord-5c2c3dd16b1a40a7a718ab15c4821040
出典データセット
uspto-grants-1981_06
特許番号
US04273779

反応ノート

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