2-Mercaptoethanol → HCID 70569286、化合物

HRID 1680641ノート

反応式

HRID 1680641 の反応式
[O:1]=[C:2]1[N:8]2[C@H:4]([O:5][C:6]([CH:9]=[CH2:10])=[CH:7]2)[CH2:3]1.[SH:11][CH2:12][CH2:13][OH:14].C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>O1CCCC1.C(OCC)(=O)C>[OH:14][CH2:13][CH2:12][S:11][CH2:10]/[CH:9]=[C:6]1/[CH2:7][N:8]2[C@H:4]([O:5]/1)[CH2:3][C:2]2=[O:1]

参加物

6

反応物 3

HCID 15672-MercaptoethanolHCID 7187Benzoyl PeroxideHCID 22807221HCID 22807221、化合物

生成物 1

HCID 70569286HCID 70569286、化合物

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

(5R)-7-Oxo-3-vinyl-4-oxa-1-azabicyclo[3.2.0] hept-2-ene (2.5 mmole) in dry tetrahydrofuran (20 ml) was treated with 2-mercaptoethanol (0.4 ml) and benzoyl peroxide (10 mg). The resulting mixture was stirred under dry nitrogen while being irradiated using a 200 W bulb placed 1" from the reaction vessel for a total time of 14 hours. The mixture was diluted with ethyl acetate (100 ml) and was washed with saturated sodium bicarbonate solution and saturated brine. The solution was dried (magnesium sulphate) and the solvent was evaporated under reduced pressure to give a yellow oil. The oil was chromatographed on silica gel (20 g) using graded elution from 1:4 to 1:1 ethyl acetate/petroleum ether (b.p. 60°-80°). The title compound was thus obtained as a colourless gum (45 mg), [α]D22 =+66.8° (c 1.0, CHCl3). νmax (CHCl3): 3370, 1795, 1695 cm-1. δ(CDCl3): 2.40 (1H, br.s, OH), 2.65 (2H, t, J 6 Hz), 2.95 (1H, d, J 16 Hz), 3.15-3.80 (6H, complex), 4.25-4.55 (2H, complex), 5.47 (1H, d, J 2 Hz). m/e: 138 (67%), 96 (100).

後処理

  1. customwhile being irradiated
  2. customfor a total time of 14 hours
  3. washwas washed with saturated sodium bicarbonate solution and saturated brine
  4. dry with materialThe solution was dried (magnesium sulphate)
  5. customthe solvent was evaporated under reduced pressure
  6. customto give a yellow oil
  7. customThe oil was chromatographed on silica gel (20 g)
  8. washelution from 1:4 to 1:1 ethyl acetate/petroleum ether (b.p. 60°-80°)

出典と根拠

ORDレコード
ord-fc791e17b13044ae8d77bb8cec2dfe12
出典データセット
uspto-grants-1981_06
特許番号
US04275067

反応ノート

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