Water → 1-([1,1'-Biphenyl]-2-yl)-2-bromoethan-1-one

HRID 1680648ノート

反応式

HRID 1680648 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:3])[CH3:2].[Br:16]Br.O>C(Cl)(Cl)Cl>[Br:16][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:3]

参加物

5

反応物 3

HCID 962WaterHCID 24408BromineHCID 111599031-((1,1'-Biphenyl)-2-yl)ethan-1-one

生成物 1

HCID 127478451-([1,1'-Biphenyl]-2-yl)-2-bromoethan-1-one収率 114.4%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a solution of 1.86 g of 2-acetyl-biphenyl in 10 ml of anhydrous chloroform, a solution of 1.29 g of bromine in 1.5 ml of anhydrous chloroform was added at 15°-20° C. When the addition was complete, the solution was stirred for 15 minutes, then poured into water. The chloroformic solution was washed with sodium bicarbonate and water, dried over calcium chloride and evaporated to dryness. 2.54 g of 2-bromoacetyl-biphenyl were obtained; the product could be used for reaction with imidazole without further purification.

後処理

  1. additionWhen the addition
  2. washThe chloroformic solution was washed with sodium bicarbonate and water
  3. dry with materialdried over calcium chloride
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-a69e300dba6442fa9af744af8d077b5f
出典データセット
uspto-grants-1981_06
特許番号
US04275071

反応ノート

読み込み中…