Hydrochloric Acid → 4,5,6,7-Tetrafluorobenzothiophen-2-carboxylic acid

HRID 1681297

反応式

HRID 1681297 の反応式
F[C:2]1[C:15]([F:16])=[C:14]([F:17])[C:13]([F:18])=[C:12]([F:19])[C:3]=1[CH:4]=[C:5]1[S:9]C(=S)N[C:6]1=[O:11].[OH-:20].[Na+].Cl>O>[F:19][C:12]1[C:3]2[CH:4]=[C:5]([C:6]([OH:20])=[O:11])[S:9][C:2]=2[C:15]([F:16])=[C:14]([F:17])[C:13]=1[F:18]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 49072912,3,4,5,6-Pentafluorobenzylidene rhodanine

生成物 1

HCID 109886834,5,6,7-Tetrafluorobenzothiophen-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

78 g of 2,3,4,5,6-pentafluorobenzylidene rhodanine were added in small portions to a stirred solution of 68 g of NaOH in 300 ml of water. The resultant clear red solution was heated to 90° C. for one hour, cooled in ice, acidified with concentrated HCl, and the cream coloured solid which was produced was filtered and washed. The crude product (59 g) was purified by sublimation to give 4,5,6,7-tetrafluorobenzothiophen-2-carboxylic acid having a melting point of 200° C.

後処理

  1. temperaturecooled in ice
  2. customwas produced
  3. filtrationwas filtered
  4. washwashed
  5. customThe crude product (59 g) was purified by sublimation

出典と根拠

ORDレコード
ord-037c9a762c0c4634b5d80f423aff29cb
出典データセット
uspto-grants-1992_12
特許番号
US05169983

関連ノート

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