Styrene Oxide → alpha-[[[2-(Phenylmethoxy)propyl]amino]methyl]benzenemethanol

HRID 1681349

反応式

HRID 1681349 の反応式
[CH2:1]1[O:9][CH:2]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:10]([O:17][CH:18]([CH3:21])[CH2:19][NH2:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:11]1([CH2:10][O:17][CH:18]([CH3:21])[CH2:19][NH:20][CH2:1][CH:2]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[OH:9])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

3

反応物 2

HCID 7276Styrene OxideHCID 2960152-(Benzyloxy)propan-1-amine

生成物 1

HCID 19806395alpha-[[[2-(Phenylmethoxy)propyl]amino]methyl]benzenemethanol収率 84.1%

反応条件

温度
140 °C

実験手順

A mixture of styrene oxide (1.96 g, 0.010 mol) and 2-benzyloxypropylamine (2.48 g, 0.15 mol) was heated at 140° C. for 6 hours and then allowed to cool to ambient temperature and stand for 12 hours. The solidified reaction mixture was triturated with isooctane and filtered to obtain an impure solid that was recrystallized from isooctane to obtain 2.40 g of a white solid (84% yield); mp 90°-100° C. (undefined).

後処理

  1. temperatureto cool to ambient temperature
  2. customThe solidified reaction mixture
  3. customwas triturated with isooctane
  4. filtrationfiltered
  5. customto obtain an impure solid
  6. customthat was recrystallized from isooctane

出典と根拠

ORDレコード
ord-9930972b977f40ce97126d92214321de
出典データセット
uspto-grants-1992_12
特許番号
US05171753

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