1-Methyl-3-triphenylmethyl-5-methoxycarbonyl-1,4,5,6-tetrahydropyrimidinium iodide → 1-Methyl-5-methoxycarbonyl-1,4,5,6-tetrahydropyrimidine

HRID 1681899ノート

反応式

HRID 1681899 の反応式
[I-].[CH3:2][NH+:3]1[CH2:8][CH:7]([C:9]([O:11][CH3:12])=[O:10])[CH2:6][N:5](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:4]1>C(O)(C(F)(F)F)=O>[CH3:2][N:3]1[CH2:8][CH:7]([C:9]([O:11][CH3:12])=[O:10])[CH2:6][N:5]=[CH:4]1

参加物

3

反応物 1

HCID 867464331-Methyl-3-triphenylmethyl-5-methoxycarbonyl-1,4,5,6-tetrahydropyrimidinium iodide

生成物 1

HCID 152943851-Methyl-5-methoxycarbonyl-1,4,5,6-tetrahydropyrimidine

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒2 回

実験手順

1-Methyl-3-triphenylmethyl-5-methoxycarbonyl-1,4,5,6-tetrahydropyrimidinium iodide (395 mg, 0.75 mmol) is dissolved in TFA (1 ml) with stirring in a stoppered round bottom flask at room temperature. After 18 hours stirring the excess TFA is evaporated in vacuo, and the dark residue triturated with ether. The ether is decanted leaving an oily residue that is taken up in ice cold sat. Na2CO3 and then extracted with chloroform. After drying and evaporation the chloroform fraction gave the free base which is recrystallized (chloroform/hexane) to yellow crystals 88 mg (74%) identified by 300 MHz nmr, ms m/z=156.

後処理

  1. customis evaporated in vacuo
  2. customthe dark residue triturated with ether
  3. customThe ether is decanted
  4. customleaving an oily residue that
  5. extractionextracted with chloroform
  6. customAfter drying
  7. customevaporation the chloroform fraction
  8. customgave the free base which
  9. customis recrystallized (chloroform/hexane) to yellow crystals 88 mg (74%)

出典と根拠

ORDレコード
ord-1b1b3693cd5f46c689e3e567c4b61b19
出典データセット
uspto-grants-1992_12
特許番号
US05175166

反応ノート

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