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反応

Benzene → 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(3-methylphenyl)ethanol

HRID 1682728

印刷プレビュー

反応式

HRID 1682728 の反応式

[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)[OH:4].O=[C:13]([CH3:27])[CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([O:25][CH3:26])=[O:24])=[CH:18][CH:17]=1.C1C=CC=CC=1.C([BH3-])#N.[Na+]>CO>[CH3:26][O:25][C:23]([CH2:22][C:19]1[CH:18]=[CH:17][C:16]([O:15][CH2:14][CH:13]([NH:1][CH2:2][CH:3]([C:5]2[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=2)[OH:4])[CH3:27])=[CH:21][CH:20]=1)=[O:24]

参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 241Benzene

HCID 5003444Sodium cyanoborohydride

HCID 134825112-Amino-1-(3-methylphenyl)ethan-1-ol

HCID 21832178Methyl 4-(2-oxopropoxy)phenylacetate

生成物 1

HCID 543607122-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(3-methylphenyl)ethanol収率 54.1%

試薬・触媒・溶媒 1

HCID 887

Methanol

溶媒

実験手順

Following a procedure similar to that described in Example 3, but using 2.5 g of 2-amino-1-(3-methylphenyl)ethanol (prepared as described in Preparation 44), 4.4 g of methyl 4-(2-oxopropoxy)phenylacetate (prepared as described in Preparation 3), 80 ml of benzene, 60 ml of absolute methanol and 4.5 g of sodium cyanoborohydride, and then purifying the reaction product by column chromatography through silica gel, using ethyl acetate as the eluent, 3.2 g of the title compound were obtained having an Rf=0.24 (thin layer chromatography over silica gel, using ethyl acetate as the developing solvent).

後処理

custompurifying the reaction product by column chromatography through silica gel

出典と根拠

ORDレコード: ord-1753d03bfac343498e0490845f1f8afd
出典データセット: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05635534

反応ノート

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