Sodium Hydroxide → 1-[2-[1-Benzoyl-3-(3,4-dichlorophenyl)-pyrrolidin-3-yl]-ethyl]-4-phenylpiperidine-4-carboxylic acid
反応式
C[O:2][C:3]([C:5]1([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][C:13]2([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=3)[CH2:17][CH2:16][N:15]([C:18](=[O:25])[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:14]2)[CH2:7][CH2:6]1)=[O:4].[OH-].[Na+]>C(O)C>[C:18]([N:15]1[CH2:16][CH2:17][C:13]([CH2:12][CH2:11][N:8]2[CH2:7][CH2:6][C:5]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)([C:3]([OH:4])=[O:2])[CH2:10][CH2:9]2)([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[C:28]([Cl:33])[CH:27]=2)[CH2:14]1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
1-[2-[1-Benzoyl-3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid methyl ester (0.2850 g, 0.5 mmol) was dissolved in ethanol (10 mL) and treated with 1M sodium hydroxide (5 mL, 5 mmol) at 20° C. for 2 hours. The aqueous phase was washed with ethyl acetate. The aqueous phase was acidified with 1N hydrochloric acid, and then extracted with ethyl acetate. The organic phase was dried over magnesium sulfate, filtered, and concentrated in vacuo to give 0.117 g (43%) of the title compound.