Methanol → Methyl 4-phenylpiperidine-4-carboxylate hydrochloride
反応式
Cl.[C:2]1([C:8]2([C:14]([OH:16])=[O:15])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17]O.O=S(Cl)[Cl:21]>C(OCC)C>[ClH:21].[CH3:17][O:15][C:14]([C:8]1([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)=[O:16]参加物
5
実験手順
4-phenyl-piperidine-4-carboxylic acid hydrochloride (from example 20.6) (2.67 g, 11 mmol) and methanol (35 mL) were combined. SOCl2 (0.9 mL, 12.34 mmol, 1.1 eq.) was added dropwise. The reaction was heated at reflux for 18 h. The reaction was concentrated in vacuo to obtain a residue. The residue was slurried in diethyl ether, filtered, and the solids were rinsed with diethyl ether to give the title compound.
後処理
- temperatureThe reaction was heated
- temperatureat reflux for 18 h
- concentrationThe reaction was concentrated in vacuo
- customto obtain a residue
- filtrationfiltered
- washthe solids were rinsed with diethyl ether
出典と根拠
- ORDレコード
- ord-5bdd2c66613f4fe880bd72984130e3bc
- 出典データセット
- uspto-grants-1997_06
- 特許番号
- US05635510
反応ノート
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