Potassium Acetate → 3-Acetoxy-7-bromo-2,3-dihydro-2,2-dimethylbenzofuran

HRID 1683687

反応式

HRID 1683687 の反応式
Br[CH:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Br:11])[C:5]=2[O:4][C:3]1([CH3:13])[CH3:12].[C:14]([O-:17])(=[O:16])[CH3:15].[K+]>CN(C)C=O>[C:14]([O:17][CH:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Br:11])[C:5]=2[O:4][C:3]1([CH3:13])[CH3:12])(=[O:16])[CH3:15]

参加物

4

反応物 2

HCID 517044Potassium AcetateHCID 190407783,7-Dibromo-2,3-dihydro-2,2-dimethylbenzofuran

生成物 1

HCID 190407903-Acetoxy-7-bromo-2,3-dihydro-2,2-dimethylbenzofuran

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 7.6 grams (0.025 mole) of 3,7-dibromo-2,3-dihydro-2,2-dimethylbenzofuran and 11.3 grams (0.115 mole) of powdered potassium acetate in 125 mL of dry N,N-dimethylformamide is stirred at ambient temperature for about 24 hours. After this time, the reaction mixture is concentrated under reduced pressure to a residue. The residue is poured into about 350 mL of water and the mixture is extracted with diethyl ether. The ether extract is concentrated under reduced pressure, yielding 3-acetoxy-7-bromo-2,3-dihydro-2,2-dimethylbenzofuran.

後処理

  1. concentrationAfter this time, the reaction mixture is concentrated under reduced pressure to a residue
  2. additionThe residue is poured into about 350 mL of water
  3. extractionthe mixture is extracted with diethyl ether
  4. extractionThe ether extract
  5. concentrationis concentrated under reduced pressure

出典と根拠

ORDレコード
ord-b440da6bf18c4451bca4470adaae49ee
出典データセット
uspto-grants-1997_06
特許番号
US05639753

関連ノート

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