2-Bromo-1-(4-hydroxyphenyl)ethanone → Bromide ion

HRID 1683719

反応式

HRID 1683719 の反応式
NC1N(CCN2CCOCC2)C2C=CC=CC=2N=1.[OH:19][C:20]1[CH:29]=[CH:28][C:23]([C:24](=[O:27])[CH2:25][Br:26])=[CH:22][CH:21]=1>C(Cl)(Cl)Cl.C(OCC)(=O)C>[OH:19][C:20]1[CH:29]=[CH:28][C:23]([C:24](=[O:27])[CH3:25])=[CH:22][CH:21]=1.[Br-:26]

参加物

6

反応物 2

HCID 49642-Bromo-1-(4-hydroxyphenyl)ethanoneHCID 5680111-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole

生成物 2

HCID 259Bromide ionHCID 74694'-Hydroxyacetophenone

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 2-amino-1-(2-morpholinoethyl)benzimidazole (10 mmol, 2.46 g) and 4-hydroxyphenacyl bromide (10 mmol, 2.15 g) (obtained by bromination of parahydroxyacetophenone with cuptic bromide in a mixture of chloroform and ethyl acetate) is heated at reflux for 1 hour in 10 ml of dimethylformamide. After cooling, the mixture is poured into 50 ml of water and rendered alkaline with ammonium hydroxide. The resulting oil is removed and treated with water. The crystallised residue is filtered, dried, and recrystallised from ethanol.

出典と根拠

ORDレコード
ord-fbf72edcbdf84c8588c19e90bbd2b9b4
出典データセット
uspto-grants-1997_06
特許番号
US05639756

関連ノート

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