Hydrochloric Acid → 1-(4-chlorophenyl)-2-(3,4-dihydropyrimido[1,2-a]benzimidazol-10(2H)-yl)ethanol

HRID 1683729ノート

反応式

HRID 1683729 の反応式
[BH4-].[Na+].[Cl:3][C:4]1[CH:25]=[CH:24][C:7]([C:8](=[O:23])[CH2:9][N:10]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[N:12]3[CH2:19][CH2:20][CH2:21][N:22]=[C:11]23)=[CH:6][CH:5]=1.Cl>C(O)C>[OH:23][CH:8]([C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:25][CH:24]=1)[CH2:9][N:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]2[CH2:19][CH2:20][CH2:21][N:22]=[C:11]12

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 791782HCID 791782、化合物HCID 4311764Sodium borohydride

生成物 1

HCID 28997651-(4-chlorophenyl)-2-(3,4-dihydropyrimido[1,2-a]benzimidazol-10(2H)-yl)ethanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Add 0.35 g (9.3 mmol) of sodium borohydride in small portions, with vigorous stirring, to a suspension of 3.0 g (9.3 mmol) of 10-(4-chlorophenacyl)-2,3,4,10-tetrahydropyrimidino[1,2-a]benzimidazole (obtained in Example 50) in 20 ml of ethanol. Maintain stirring for one hour and leave for 12 hours at room temperature. Acidify with hydrochloric acid, and evaporate the reaction mixture. Treat the residue with ammonium hydroxide and extract with chloroform. The organic phase obtained is passed over a column of alumina. Evaporate the solvent. The residue is the title compound.

後処理

  1. temperatureMaintain
  2. customleave for 12 hours at room temperature
  3. customevaporate the reaction mixture
  4. additionTreat the residue with ammonium hydroxide
  5. extractionextract with chloroform
  6. customThe organic phase obtained
  7. customEvaporate the solvent

出典と根拠

ORDレコード
ord-1cbd5d10e6604fc8bd394ae2639bf8b0
出典データセット
uspto-grants-1997_06
特許番号
US05639756

反応ノート

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