Hydrazine hydrate (1:1) → 5-(4-Chloro-phenyl)-2,4-dihydro-pyrazol-3-one

HRID 1683810ノート

反応式

HRID 1683810 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]([C:8](C)(C)[C:9](OCC)=[O:10])=O)=[CH:4][CH:3]=1.O.[NH2:19][NH2:20]>C(O)C>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]2[CH2:8][C:9](=[O:10])[NH:20][N:19]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 16638375HCID 16638375、化合物

生成物 1

HCID 47787935-(4-Chloro-phenyl)-2,4-dihydro-pyrazol-3-one収率 82,212.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 26 g (0.10 mmol) of ethyl α-(4-chlorobenzoyl)isobutyrate, 10 g (0.20 mmol) of hydrazine monohydrate and 200 ml of ethanol was heated under reflux for 18 hours. The reaction solution was concentrated under reduced pressure. The obtained crude product was washed successively with water, methanol-water and diethyl ether-n-hexane, and then air dried to give 16 g of the object compound as white crystals (yield 84%).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. customThe obtained crude product
  5. washwas washed successively with water, methanol-water and diethyl ether-n-hexane
  6. customair dried

出典と根拠

ORDレコード
ord-5449332995294ab599caac6f51e011c8
出典データセット
uspto-grants-1997_06
特許番号
US05639776

反応ノート

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