Ethanol → HCID 138962963、化合物
反応式
[O-][CH2:2]C.[Na+].C(O)C.CI.[C:10]([NH:15][C:16]([NH2:18])=[S:17])([O:12][CH2:13][CH3:14])=[O:11]>CCOCC>[CH3:2][S:17][C:16](=[NH:18])[NH:15][C:10]([O:12][CH2:13][CH3:14])=[O:11]参加物
6
反応条件
- 温度
- 21 °C
実験手順
To a solution of sodium ethoxide in ethanol (made by addition of sodium (0.155 g, 6.7 mmol) to dry ethanol(15 ml)) was added methyl iodide (1.47 ml, 23.6 mmol) followed by N-carbethoxythiourea (1.0 g, 6.7 mmol). The resulting solution was stirred at 21° C. under nitrogen for 1 hr. This was then treated with ether (32 ml) and the resultant precipitate filtered off. The filtrate was evaporated to a clear syrup, which crystallised at 0-4° C. to give the title compound as a white solid (0.815 g).
後処理
- filtrationthe resultant precipitate filtered off
- customThe filtrate was evaporated to a clear syrup, which
- customcrystallised at 0-4° C.
出典と根拠
- ORDレコード
- ord-0eb51fa9da2b4042ba507f479c3d4131
- 出典データセット
- uspto-grants-1997_06
- 特許番号
- US05639786
反応ノート
読み込み中…