Hydrochloric Acid → [2-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl) phenyl]methanol

HRID 1684004ノート

反応式

HRID 1684004 の反応式
[Br:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[C:20](O)=[O:21])=[C:8]2[CH3:27])=[CH:4][CH:3]=1.S(C)C.Cl.C(OCC)(=O)C>C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[CH2:20][OH:21])=[C:8]2[CH3:27])=[CH:28][CH:29]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 1068Dimethyl SulfideHCID 8857Ethyl AcetateHCID 538358182-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1 H-indol-3-yl) benzoic acid

生成物 1

HCID 53681185[2-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl) phenyl]methanol収率 99%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of the acid from Step 1 (300 mg, 0.66 mmol) and BH3 Σ SMe2 (0.1 mL, 1 mmol) in THF (3 mL) was gently refluxed for 2 h. The cooled mixture was poured over icy dilute HCl and ethyl acetate. The organic layer was washed with brine and dried with MgSO4. Removal of the solvents yielded essentially pure product (285 mg).

後処理

  1. washThe organic layer was washed with brine
  2. dry with materialdried with MgSO4
  3. customRemoval of the solvents

出典と根拠

ORDレコード
ord-25e6c5aab31546c49772fa68aa7db7e3
出典データセット
uspto-grants-1997_06
特許番号
US05639780

反応ノート

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