Sodium borohydride → {3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}methanol

HRID 1684908ノート

反応式

HRID 1684908 の反応式
[BH4-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][C:15]([C:18]4[C:19]([F:26])=[C:20]([CH:23]=[CH:24][CH:25]=4)[CH:21]=[O:22])=[CH:14][N:13]3[CH:27]=2)=[CH:6][CH:5]=1>CO>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][C:15]([C:18]4[C:19]([F:26])=[C:20]([CH2:21][OH:22])[CH:23]=[CH:24][CH:25]=4)=[CH:14][N:13]3[CH:27]=2)=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 86651935HCID 86651935、化合物

生成物 1

HCID 44231745{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}methanol収率 57.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

162 mg of sodium borohydride are added portionwise to 150 mg of 3-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorobenzaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 2 hours and then the solvent is evaporated under reduced pressure. The residue is taken up between water and dichloromethane and the organic phase is separated, dried over sodium sulphate and evaporated under reduced pressure. The residue is purified by chromatography on silica gel, elution being carried out with a dichloromethane/methanol 98/02 mixture. 87 mg of compound are obtained.

後処理

  1. customthe solvent is evaporated under reduced pressure
  2. customthe organic phase is separated
  3. dry with materialdried over sodium sulphate
  4. customevaporated under reduced pressure
  5. customThe residue is purified by chromatography on silica gel, elution

出典と根拠

ORDレコード
ord-6f275abcd02440a383bcc838b6fa7230
出典データセット
uspto-grants-2012_04
特許番号
US08148370B2

反応ノート

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