Sodium borohydride → 3-Bromo-2-fluorobenzyl Alcohol

HRID 1684918

反応式

HRID 1684918 の反応式
[Br:1][C:2]1[C:3]([F:10])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[BH4-].[Na+]>CO>[Br:1][C:2]1[C:3]([F:10])=[C:4]([CH2:5][OH:6])[CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 220193613-Bromo-2-fluorobenzaldehyde

生成物 1

HCID 269856463-Bromo-2-fluorobenzyl Alcohol収率 77.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2.00 g of 3-bromo-2-fluorobenzaldehyde are dissolved in 98 ml of methanol; 560 mg of sodium borohydride are added portionwise thereto. The mixture is stirred at ambient temperature for 2 hours and then the solvent is evaporated under reduced pressure. The residue is taken up between water and ethyl acetate and the organic phase is separated, dried and concentrated under reduced pressure. The residue is purified by chromatography on silica gel, elution being carried out with a dichloromethane/methanol mixture. 1.56 g of compound are obtained.

後処理

  1. customthe solvent is evaporated under reduced pressure
  2. customthe organic phase is separated
  3. customdried
  4. concentrationconcentrated under reduced pressure
  5. customThe residue is purified by chromatography on silica gel, elution

出典と根拠

ORDレコード
ord-353e33ce6a734bccb2cc1491d02fb782
出典データセット
uspto-grants-2012_04
特許番号
US08148370B2

関連ノート

読み込み中…