Sodium borohydride → (2-Bromo-6-fluorophenyl)methanol

HRID 1684924ノート

反応式

HRID 1684924 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][OH:5]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 224739772-Bromo-6-fluorobenzaldehyde

生成物 1

HCID 44181801(2-Bromo-6-fluorophenyl)methanol収率 90.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

20.0 g (0.098 mol) of 2-bromo-6-fluorobenzaldehyde are dissolved in 500 ml of methanol and cooled in an ice bath; 3.72 g (0.098 mol) of sodium borohydride are then added portionwise thereto. The mixture is stirred under cold conditions for 1 hour and then the solid is evaporated under reduced pressure. The residue is taken up between water and dichloromethane and the organic phase is separated, dried and concentrated under reduced pressure. The residue is crystallised from pentane. 18.1 g of compound are obtained.

後処理

  1. temperaturecooled in an ice bath
  2. customthe solid is evaporated under reduced pressure
  3. customthe organic phase is separated
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customThe residue is crystallised from pentane

出典と根拠

ORDレコード
ord-ca4daeefeadc4e0284d05a297a0deaf5
出典データセット
uspto-grants-2012_04
特許番号
US08148370B2

反応ノート

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