Butylamine → N2-butyl-9H-purine-2,6-diamine

HRID 1684963ノート

反応式

HRID 1684963 の反応式
Cl[C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1.[CH2:12]([NH2:16])[CH2:13][CH2:14][CH3:15]>>[CH2:12]([NH:16][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1)[CH2:13][CH2:14][CH3:15]

参加物

3

反応物 2

HCID 8007ButylamineHCID 949042-Chloroadenine

生成物 1

HCID 3487963N2-butyl-9H-purine-2,6-diamine収率 30%

実験手順

2-Chloroadenine (6.0 g, 35.4 mmol) and n-butylamine (30 ml) were reacted in an autoclave (200 ml) at 130° C. for 150 hours. After the reaction mixture was concentrated under reduced pressure, the residue was poured into water to precipitate the solid. The precipitated solid was successively washed with methylene chloride and methanol to give the captioned compound (2.08 g, yield 30%) as a yellowish orange powdered solid.

後処理

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure
  2. additionthe residue was poured into water
  3. customto precipitate the solid
  4. washThe precipitated solid was successively washed with methylene chloride and methanol

出典と根拠

ORDレコード
ord-5120daebfcee4199a866e8c799b01124
出典データセット
uspto-grants-2012_04
特許番号
US08148371B2

反応ノート

読み込み中…