Hydrochloric Acid → (5-Chlorothiophen-3-yl)methanamine hydrochloride
反応式
B.C1COCC1.[Cl:7][C:8]1[S:12][CH:11]=[C:10]([C:13]#[N:14])[CH:9]=1.Cl.O.CO>C1COCC1>[ClH:7].[Cl:7][C:8]1[S:12][CH:11]=[C:10]([CH2:13][NH2:14])[CH:9]=1参加物
6
実験手順
To a pre-cooled (ice-water bath) solution of BH3.THF (3.4 eq, 11.8 mL) was added a solution of 5-chlorothiophene-3-carbonitrile (0.5 g, 3.48 mmol) in THF (11.5 ml). The reaction mixture was stirred for 4 hours at room temperature and subsequently 6 N HCl (17 ml) was added slowly followed by H2O/MeOH (17/114 mL). The reaction mixture was stirred overnight. Removal of the volatiles afforded the title product (1.0 g) as an off-white solid.
後処理
- stirringThe reaction mixture was stirred overnight
- customRemoval of the volatiles
出典と根拠
- ORDレコード
- ord-e7da5c790395419ea648a7b77070da1d
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08148380B2
反応ノート
読み込み中…