Trifluoroacetic acid → (R)-tetrahydro-furan-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-methyl-amide

HRID 1685069ノート

反応式

HRID 1685069 の反応式
C(OC(=O)[NH:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][N:14]([CH3:22])[C:15]([C@H:17]2[CH2:21][CH2:20][CH2:19][O:18]2)=[O:16])[N:12]=1)(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][N:14]([CH3:22])[C:15]([C@H:17]2[CH2:21][CH2:20][CH2:19][O:18]2)=[O:16])[N:12]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 86661307(4-{[methyl-((R)-tetrahydro-furan-2-carbonyl)-amino]-methyl}-thiazol-2-yl)-carbamic acid tert-butyl ester

生成物 1

HCID 86661308(R)-tetrahydro-furan-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-methyl-amide

実験手順

The product from Step 1 was treated with TFA to cleave the BOC group (Method 1) to afford (R)-tetrahydro-furan-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-methyl-amide.

出典と根拠

ORDレコード
ord-bb597e1ad90f430a8deee0472d118142
出典データセット
uspto-grants-2012_04
特許番号
US08148380B2

反応ノート

読み込み中…