Chloroacetonitrile → HCID 44542641、化合物

HRID 1685097ノート

反応式

HRID 1685097 の反応式
[NH2:1][C:2]1[C:3]2[CH:14]=[C:13]([Br:15])[CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8].[Cl:16][CH2:17][C:18]#[N:19]>Cl.O1CCOCC1>[NH2:19][C:18](=[N:1][C:2]1[C:3]2[CH:14]=[C:13]([Br:15])[CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8])[CH2:17][Cl:16]

参加物

5

反応物 2

HCID 7856ChloroacetonitrileHCID 44542789Methyl 3-amino-5-bromo-1-benzothiophene-2-carboxylate

生成物 1

HCID 44542641HCID 44542641、化合物

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 312751,4-Dioxane溶媒

実験手順

A suspension of EXAMPLE 1A (7.2 g, 25.16 mmol) in 4N hydrochloric acid in dioxane (70 mL) was treated with 2-chloroacetonitrile (3.18 mL, 50.32 mmol) at ambient temperature for 3 hours. The white solid was collected by filtration and dried to give the title compound as the hydrochloride salt. LCMS (APCI) m/z: 362(M+H)+.

後処理

  1. filtrationThe white solid was collected by filtration
  2. customdried

出典と根拠

ORDレコード
ord-f5122d728e384fb5b448e893fe3bb9a7
出典データセット
uspto-grants-2012_04
特許番号
US08148384B2

反応ノート

読み込み中…