Thionyl Chloride → 3-(chloromethyl)-2-ethylPyridine
反応式
[CH2:1]([C:3]1[C:8]([CH2:9]O)=[CH:7][CH:6]=[CH:5][N:4]=1)[CH3:2].S(Cl)([Cl:13])=O>C(Cl)Cl>[CH2:1]([C:3]1[C:8]([CH2:9][Cl:13])=[CH:7][CH:6]=[CH:5][N:4]=1)[CH3:2]参加物
4
反応条件
- 温度
- 0 °C
実験手順
The 2-ethyl-3-hydroxymethylpyridine (2.3 g, 16.8 mmol) was dissolved in CH2Cl2 (100 mL) and cooled under nitrogen to 0° C. and thionyl chloride (7.0 mL) was slowly added and the reaction was stirred for 3 hours. The solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was dried with MgSO4, filtered, and the solvent removed under reduced pressure to give the desired 2-ethyl-3-chloromethylpyridine.
後処理
- customThe solvent was removed under reduced pressure
- customthe residue was partitioned between CH2Cl2 (100 mL) and saturated aqueous sodium bicarbonate (100 mL)
- dry with materialThe organic layer was dried with MgSO4
- filtrationfiltered
- customthe solvent removed under reduced pressure
出典と根拠
- ORDレコード
- ord-090d23f63738479ca8c99ffd51c34f39
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05726172
反応ノート
読み込み中…