Morpholine → 4-[(3-Chloro-4-fluorophenyl)sulfonyl]morpholine

HRID 1686445

反応式

HRID 1686445 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[Cl:12].[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>C(Cl)Cl>[Cl:12][C:3]1[CH:4]=[C:5]([S:8]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)(=[O:10])=[O:9])[CH:6]=[CH:7][C:2]=1[F:1]

参加物

4

反応物 2

HCID 8083MorpholineHCID 1452223-Chloro-4-fluorobenzenesulphonyl chloride

生成物 1

HCID 6978264-[(3-Chloro-4-fluorophenyl)sulfonyl]morpholine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-fluoro-3-chlorobenzenesulphonyl chloride (0.9 g) was stirred in dry DCM (10 ml) and morpholine (0.69 ml) added. The mixture was allowed to stir at RT for 1 h and then quenched with water, extracted with DCM, dried (MgSO4) and evaporated under reduced pressure to give a white solid (1.10 g).

後処理

  1. customquenched with water
  2. extractionextracted with DCM
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-9630a25f50aa454dade9a9dfd6f7ac7e
出典データセット
uspto-grants-2012_04
特許番号
US08148572B2

関連ノート

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