Dimethylformamide → 3-Azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 1687634ノート

反応式

HRID 1687634 の反応式
I[CH:2]1[CH2:8][C:7]([CH3:10])([CH3:9])[C:6]2[CH:11]=[CH:12][C:13]([N+:15]([O-:17])=[O:16])=[CH:14][C:5]=2[NH:4][C:3]1=[O:18].[N-:19]=[N+:20]=[N-:21].[Na+].CN(C=O)C>>[N:19]([CH:2]1[CH2:8][C:7]([CH3:10])([CH3:9])[C:6]2[CH:11]=[CH:12][C:13]([N+:15]([O-:17])=[O:16])=[CH:14][C:5]=2[NH:4][C:3]1=[O:18])=[N+:20]=[N-:21]

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 33557Sodium AzideHCID 672643563-Iodo-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one

生成物 1

HCID 866339913-Azido-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one

実験手順

3-Iodo-5,5-dimethyl-8-nitro-1,3,4,5-tetrahydro-1-benzazepin-2-one (5.367 g, 0.015 mol), Sodium azide (6.49 g, 0.1 mol), and DMF (100 mL, 2 mol) were stirred at rt for 2 h. The reaction mixture was diluted with H20 and the resulting beige ppt was filtered.

後処理

  1. additionThe reaction mixture was diluted with H20
  2. filtrationthe resulting beige ppt was filtered

出典と根拠

ORDレコード
ord-8f7adc16f7244274895898e7c92241f0
出典データセット
uspto-grants-2012_04
特許番号
US08148391B2

反応ノート

読み込み中…