3-Nitro-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocycloheptene → 6,7,8,9-Tetrahydro-5-oxa-9-aza-benzocyclohepten-3-ylamine
反応式
[N+:1]([C:4]1[CH:14]=[CH:13][C:7]2[NH:8][CH2:9][CH2:10][CH2:11][O:12][C:6]=2[CH:5]=1)([O-])=O>[Pd].C(O)C>[CH:13]1[C:7]2[NH:8][CH2:9][CH2:10][CH2:11][O:12][C:6]=2[CH:5]=[C:4]([NH2:1])[CH:14]=1参加物
4
実験手順
3-Nitro-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocycloheptene (281 mg, 1.45 mmol) and 10% Palladium on Carbon (50% Wet) (77 mg) in Ethanol (10 mL) was shaken under an atmosphere of Hydrogen (50 psi) for 5 h, filtered and conc. to give 6,7,8,9-Tetrahydro-5-oxa-9-aza-benzocyclohepten-3-ylamine (230 mg, 97%). 1H-NMR (CDCl3): 6.58 (d, 1H, J=8.1 Hz), 6.40 (s, 1H), 6.27 (d, 1H, J=8.1 Hz), 4.01 (m, 2H), 3.39 (br s, 3H), 3.10 (m, 2H), 1.97 (m, 2H).
後処理
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-9a555fb03ed34a0e83e331499dfe1a87
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08148391B2
反応ノート
読み込み中…