Hydrochloric Acid → 2-Amino-3-chloro-5-fluorobenzoic acid

HRID 1688071ノート

反応式

HRID 1688071 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([F:13])[CH:5]=[C:6]2[C:10]=1[NH:9]C(=O)[C:7]2=[O:12].[OH:14]O.Cl>[OH-].[Na+]>[NH2:9][C:10]1[C:2]([Cl:1])=[CH:3][C:4]([F:13])=[CH:5][C:6]=1[C:7]([OH:12])=[O:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 167936797-Chloro-5-fluoroindoline-2,3-dione

生成物 1

HCID 289741482-Amino-3-chloro-5-fluorobenzoic acid

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of 7-chloro-5-fluoro-1H-indole-2,3-dione (270 mg) in 1 M sodium hydroxide solution (5 mL) was treated with 30% hydrogen peroxide (5 mL) via dropwise addition. After one hour of stirring, the reaction was acidified with HCl to pH 1, and extracted three times with ethyl acetate. The combined organic layers were dried with sodium sulfate, and concentrated in vacuo to provide 200 mg of 2-amino-3-chloro-5-fluoro-benzoic acid.

後処理

  1. extractionextracted three times with ethyl acetate
  2. dry with materialThe combined organic layers were dried with sodium sulfate
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-0d481ba1bf90484299f730d08205605b
出典データセット
uspto-grants-2012_04
特許番号
US08148391B2

反応ノート

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