Sodium borohydride → (5-(2-(tert-Butyldimethylsilyloxy)ethyl)thiophen-2-yl)methanol
反応式
[BH4-].[Na+].[Si:3]([O:10][CH2:11][CH2:12][C:13]1[S:17][C:16]([CH:18]=[O:19])=[CH:15][CH:14]=1)([C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:5])[CH3:4]>C(O)C>[Si:3]([O:10][CH2:11][CH2:12][C:13]1[S:17][C:16]([CH2:18][OH:19])=[CH:15][CH:14]=1)([C:6]([CH3:8])([CH3:9])[CH3:7])([CH3:5])[CH3:4]参加物
4
反応条件
- 温度
- 0 °C
実験手順
Sodium borohydride (1.74 g) was added to a solution of 5-(2-(tert-butyldimethylsilyloxy)ethyl)thiophene-2-carbaldehyde (12.4 g) (example 4, step b) in ethanol (120 mL) at 0° C. The resulting solution was stirred at 0° C. for 1 h. The reaction mixture was partitioned between brine and ethyl acetate. The organic layer was separated, dried over sodium sulphate, filtered and the solvent evaporated in vacuo to give the subtitled compound. Yield 12.1 g.