4-Methyl-2-oxovaleric acid → Methyl 4-methyl-2-oxopentanoate

HRID 1689750ノート

反応式

HRID 1689750 の反応式
[CH3:1][CH:2]([CH3:9])[CH2:3][C:4](=[O:8])[C:5]([OH:7])=[O:6].Cl[Si](C)(C)[CH3:12]>CO.COC(OC)(C)C>[CH3:12][O:6][C:5](=[O:7])[C:4](=[O:8])[CH2:3][CH:2]([CH3:9])[CH3:1]

参加物

5

反応物 2

HCID 704-Methyl-2-oxovaleric acidHCID 6397Chlorotrimethylsilane

生成物 1

HCID 546077Methyl 4-methyl-2-oxopentanoate

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 64952,2-Dimethoxypropane溶媒

実験手順

To a solution of 4-methyl-2-oxo-pentanoic acid (3.4 g, 26 mmol) in methanol (12 mL) and 2,2-dimethoxypropane (48 mL) is added chlorotrimethylsilane (0.38 mL). The reaction mixture is stirred at ambient temperature overnight. The reaction mixture is concentrated under reduced pressure to give the title compound as an oil, (3.8 g, quant.). 1H NMR (400 MHz, CDCl3): δ 3.86 (s, 3H), 2.72 (d, 2H), 2.16 (m, 1H), 0.96 (d, 6H).

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-bcf4c942452542b2835469abebe17bbc
出典データセット
uspto-grants-2012_04
特許番号
US08153624B2

反応ノート

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