反応式
[CH2:1]([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])[CH3:2].CN(C(ON1N=N[C:18]2[CH:19]=[CH:20][CH:21]=N[C:17]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CS(C)=[O:34].[CH3:36][OH:37]>N1C=CC=CC=1>[N:3]1([CH2:6][CH2:7][C:36]([OH:34])=[O:37])[C:4]2[C:20](=[CH:19][CH:18]=[CH:17][CH:5]=2)[CH2:21][CH2:2][CH2:1]1参加物
5
実験手順
A mixture of the corresponding acid (0.2 mmol), amine (0.2 mmol), triethylamine (28 μL, 0.2 mmol) and HATU (76 mg, 0.2 mmol) in pyridine (0.5 mL) was microwaved at 200° C. for 420 s. The reaction mixture was diluted with 50% DMSO/MeOH (0.5 mL), filtered and purified by HPLC (gradient of 10-99% CH3CN/water).
後処理
- customwas microwaved at 200° C. for 420 s
- filtrationfiltered
- custompurified by HPLC (gradient of 10-99% CH3CN/water)
出典と根拠
- ORDレコード
- ord-b1dcbd58a05448e699d0959800dfe7f1
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08153655B2
関連ノート
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