Triethylamine → 3-(3-Fluoro-4-isocyanato-phenyl)-propionic acid tert-butyl ester

HRID 1690564ノート

反応式

HRID 1690564 の反応式
[C:1]([O:5][C:6](=[O:17])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([F:16])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Cl[C:19](Cl)([O:21]C(=O)OC(Cl)(Cl)Cl)Cl.CCN(CC)CC>C(Cl)Cl>[C:1]([O:5][C:6](=[O:17])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]=[C:19]=[O:21])=[C:11]([F:16])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 94429TriphosgeneHCID 66905628Tert-butyl 3-(4-amino-3-fluorophenyl)propanoate

生成物 1

HCID 866402673-(3-Fluoro-4-isocyanato-phenyl)-propionic acid tert-butyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In analogy to the procedure described in example 9.1, 3-(4-amino-3-fluoro-phenyl)-propionic acid tert-butyl ester was reacted with triphosgene in the presence of Et3N in CH2Cl2 under reflux conditions for 20 h to give the title compound as yellow oil which was used in the next step without further purification. MS: m/e=265.1 [M+].

出典と根拠

ORDレコード
ord-e95c33b171d949e58ecc0610fb2bd4ec
出典データセット
uspto-grants-2012_04
特許番号
US08153663B2

反応ノート

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