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3-Ethoxyaniline → [5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Ethoxyaniline | HCID 12120 | — |
| 反応物 | 3-chloro-2-(4-chloro-phenyl)-2H-indazole | HCID 2776903 | — |
| 反応物 | 3,5-Dichloro-2-(4-chlorophenyl)-2H-indazole | HCID 13143684 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | [5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine | HCID 66905404 | — |
反応手順
In analogy to the procedure described in example 4.1, a mixture of 3,5-dichloro-2-(4-chloro-phenyl)-2H-indazole and 3-chloro-2-(4-chloro-phenyl)-2H-indazole was reacted with 3-ethoxy-phenylamine ([621-33-0]) in N-methyl 2-pyrrolidone for 4 d at 175° C. in a sealed tube to give the title compound after purification by column chromatography (silica gel, iPrOAc/heptane) as yellow foam. MS: m/e=398.1 [M+H+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08153663B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-a64b007b2b2c4ed0acaeb08f703d1a16 |
| 出典メモ | uspto-grants-2012_04 |