Triethylamine → 1-[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(3-ethoxy-phenyl)-urea

HRID 1690572

反応式

HRID 1690572 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[C:5]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH2:26][CH3:27])[CH:20]=3)[N:6]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=3)[N:7]=2)[CH:3]=1.[CH:28]1([N:34]=[C:35]=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1.CCN(CC)CC>ClCCCl>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[C:5]([N:18]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH2:26][CH3:27])[CH:20]=3)[C:35]([NH:34][CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)=[O:36])[N:6]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=3)[N:7]=2)[CH:3]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 18502Cyclohexyl isocyanateHCID 66905404[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine

生成物 1

HCID 451113281-[5-Chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-1-(3-ethoxy-phenyl)-urea

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

In analogy to the procedure described in example 1.2, [5-chloro-2-(4-chloro-phenyl)-2H-indazol-3-yl]-(3-ethoxy-phenyl)-amine was reacted with cyclohexylisocyanate ([3173-53-3]) in 1,2-dichloroethane in the presence of Et3N (3 eq.) for 4 days under reflux conditions to give the title compound as colorless foam. MS: m/e=523.3 [M+H+].

出典と根拠

ORDレコード
ord-527921a53d2e412c9dffc5861238d93c
出典データセット
uspto-grants-2012_04
特許番号
US08153663B2

関連ノート

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