Lithium Hydroxide → HCID 45111769、化合物
反応式
C[O:2][C:3](=[O:36])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([N:13]([CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[C:14]2[N:15]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:16]=[C:17]3[C:22]=2[CH2:21][CH2:20][CH2:19][CH2:18]3)=[O:12])=[C:6]([Cl:35])[CH:5]=1.[OH-].[Li+]>C(OC(C)=O)(C)C.[Cl-].[Na+].O>[Cl:35][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[NH:10][C:11]([N:13]([CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1)[C:14]1[N:15]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:16]=[C:17]2[C:22]=1[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:12])[C:3]([OH:36])=[O:2]参加物
4
実験手順
In analogy to the procedure described in example 2.2, 3-chloro-4-[3-cyclohexyl-3-(2-phenyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-ureido]-benzoic acid methyl ester was treated with 1 N aqueous lithium hydroxide solution in THF/MeOH 1/1 for 1 h at ambient temperature to give the title compound as yellow solid. MS: m/e=493.3 [M+H+].
出典と根拠
- ORDレコード