Sodium Hydroxide → thieno[2,3-b]pyridine-2-carboxylic acid

HRID 1691555

反応式

HRID 1691555 の反応式
C[O:2][C:3]([C:5]1[S:13][C:8]2=[N:9][CH:10]=[CH:11][CH:12]=[C:7]2[CH:6]=1)=[O:4].[OH-].[Na+]>CO.O>[S:13]1[C:8]2=[N:9][CH:10]=[CH:11][CH:12]=[C:7]2[CH:6]=[C:5]1[C:3]([OH:4])=[O:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 19007380Methyl thieno[2,3-b]pyridine-2-carboxylate

生成物 1

HCID 7162095thieno[2,3-b]pyridine-2-carboxylic acid収率 78%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of compound 147-B (0.508 g, 2.63 mmol) in a mixture of MeOH (15 mL) and H2O (3 mL) was added 3N NaOH (1.9 mL, 5.66 mmol) and the reaction mixture was stirred at ambient temperature for 5 h. The solvent was evaporated under reduced pressure, the residue dissolved in H2O, and acidified with 1N HCl. The precipitate was filtered, washed with H2O, and dried under vacuum to afford compound 147-C as a white solid (0.366 g, 78%). MS: m/z 180.0 (MH+).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe residue dissolved in H2O
  3. filtrationThe precipitate was filtered
  4. washwashed with H2O
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-f990995312394c4c8c92e046df7071f9
出典データセット
uspto-grants-2012_04
特許番号
US08153682B2

関連ノート

読み込み中…