Sodium Hydroxide → Thieno(2,3-b)pyridine-2-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[S:13][C:8]2=[N:9][CH:10]=[CH:11][CH:12]=[C:7]2[CH:6]=1)=[O:4].[OH-].[Na+]>CO.O>[S:13]1[C:8]2=[N:9][CH:10]=[CH:11][CH:12]=[C:7]2[CH:6]=[C:5]1[C:3]([OH:4])=[O:2]参加物
5
実験手順
To a solution of compound 147-B (0.508 g, 2.63 mmol) in a mixture of MeOH (15 mL) and H2O (3 mL) was added 3N NaOH (1.9 mL, 5.66 mmol) and the reaction mixture was stirred at ambient temperature for 5 h. The solvent was evaporated under reduced pressure, the residue dissolved in H2O, and acidified with 1N HCl. The precipitate was filtered, washed with H2O, and dried under vacuum to afford compound 147-C as a white solid (0.366 g, 78%). MS: m/z 180.0 (MH+).
後処理
- customThe solvent was evaporated under reduced pressure
- dissolutionthe residue dissolved in H2O
- filtrationThe precipitate was filtered
- washwashed with H2O
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-f990995312394c4c8c92e046df7071f9
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08153682B2
反応ノート
読み込み中…