Hydrochloric Acid → (2-Bromo-5-difluoromethoxy-4-methoxy-phenyl)-acetic acid
反応式
C[O:2][C:3](=[O:18])[CH2:4][C:5]1[CH:10]=[C:9]([O:11][CH:12]([F:14])[F:13])[C:8]([O:15][CH3:16])=[CH:7][C:6]=1[Br:17].[OH-].[Li+].Cl>CO.O>[Br:17][C:6]1[CH:7]=[C:8]([O:15][CH3:16])[C:9]([O:11][CH:12]([F:14])[F:13])=[CH:10][C:5]=1[CH2:4][C:3]([OH:18])=[O:2]参加物
6
実験手順
(2-Bromo-5-difluoromethoxy-4-methoxy-phenyl)-acetic acid methyl ester (400 mg) was dissolved in 5 ml methanol and treated with 150 mg lithium hydroxide in 1 ml of water. The mixture was stirred at room temperature for 18 hours, acidified with 10% aqueous hydrochloric acid, filtered and dried to yield 350 mg of (2-bromo-5-difluoromethoxy-4-methoxy-phenyl)-acetic acid.
後処理
- filtrationfiltered
- customdried
出典と根拠
- ORDレコード
- ord-6249229d6bec4948bc8fd12be3575e24
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08153808B2
反応ノート
読み込み中…