1-Fluoro-4-methoxy-5-methyl-2-nitrobenzene → 2-Fluoro-5-methoxy-4-methylaniline

HRID 1691814ノート

反応式

HRID 1691814 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[N+:11]([O-])=O.[H][H]>CO.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([O:9][CH3:10])=[CH:4][C:3]=1[NH2:11]

参加物

5

反応物 2

HCID 598501391-Fluoro-4-methoxy-5-methyl-2-nitrobenzeneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 593777852-Fluoro-5-methoxy-4-methylaniline収率 99.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

1-Fluoro-4-methoxy-5-methyl-2-nitro-benzene (1.18 g, 6.4 mmol) was dissolved in 40 ml of methanol at room temperature. 10% Palladium on Carbon (200 mg) was added and the mixture was stirred under a balloon of hydrogen overnight. The mixture was filtered through celite. The filtrate was concentrated in vacuo to give 2-fluoro-5-methoxy-4-methyl-phenylamine (990 mg, quantitative) as a solid.

後処理

  1. filtrationThe mixture was filtered through celite
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-064546fbd954456e83c9eb21053b5c0c
出典データセット
uspto-grants-2012_04
特許番号
US08153809B2

反応ノート

読み込み中…