Ethanol → Ethyl 4-(aminomethyl)benzoate--hydrogen chloride (1/1)
反応式
[NH2:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.S(Cl)([Cl:14])=O.[CH2:16](O)[CH3:17]>>[ClH:14].[CH2:16]([O:8][C:7](=[O:9])[C:6]1[CH:5]=[CH:4][C:3]([CH2:2][NH2:1])=[CH:11][CH:10]=1)[CH3:17]参加物
4
実験手順
20.0 g (132 mM) of 4-aminomethylbenzoic acid are suspended in 200 ml ethanol (EtOH) abs. and cooled with ice. 28.0 g (17 ml) (236 mM) thionylchloride are added drop by drop. The clear mixture is then refluxed for 3 hours. After cooling to room temperature, EtOH is evaporated. 50 ml of toluene/EtOH 1/1 are added and evaporated three times. The residue is dried to get 27 g of (1).
後処理
- temperatureand cooled with ice
- temperatureThe clear mixture is then refluxed for 3 hours
- customEtOH is evaporated
- addition50 ml of toluene/EtOH 1/1 are added
- customevaporated three times
- customThe residue is dried
出典と根拠
- ORDレコード
- ord-7a93cf58ca3c4cdd854f76ca7d53162b
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158438B2
反応ノート
読み込み中…