1,4-Dioxane → HCID 66824419、化合物
反応式
[O:1]1[CH2:6][CH2:5]OCC1.[F:7][CH2:8][C:9]1([C:14]#[N:15])CC(=C)[CH2:10]1.I([O-])(=O)(=O)=O.[Na+]>O.[Os](=O)(=O)(=O)=O>[F:7][CH2:8][C:9]1([C:14]#[N:15])[CH2:5][C:6](=[O:1])[CH2:10]1参加物
6
実験手順
A mixture of water (2 mL, 0.1 mol) and 1,4-dioxane (6 mL, 0.08 mol), 1-(fluoromethyl)-3-methylenecyclobutanecarbonitrile (0.256 g, 0.00204 mol), and 0.2 M of osmium tetraoxide in water (0.04 mL) was stirred for 5 min, during which time the mixture became brown. While the temperature was maintained at room temperature, sodium periodate (0.919 g, 0.00430 mol) was added in portions over a period of 30 min. The mixture was stirred overnight. The mixture was extracted with EtOAc and combined organic layers were dried over MgSO4. After removal of the solvents, the crude product was used directly in next step.
後処理
- stirringThe mixture was stirred overnight
- extractionThe mixture was extracted with EtOAc
- dry with materialwere dried over MgSO4
- customAfter removal of the solvents
出典と根拠
- ORDレコード
- ord-dfd61e839c4747b7b3a28a24abc71094
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158616B2
反応ノート
読み込み中…