Sodium Hydroxide → 3-Methoxypyridine-2-carboxylic acid
反応式
[OH-].[Na+].[CH3:3][O:4][C:5]1[C:6]([C:11]([O:13]C)=[O:12])=[N:7][CH:8]=[CH:9][CH:10]=1>CO>[CH3:3][O:4][C:5]1[C:6]([C:11]([OH:13])=[O:12])=[N:7][CH:8]=[CH:9][CH:10]=1参加物
4
実験手順
A 5 N sodium hydroxide solution (147 μL) was added to a solution of methyl 3-methoxypyridine-2-carboxylate (112 mg) in methanol (2 mL), and the mixture was stirred at room temperature overnight. The excess of methanol was evaporated under reduced pressure, and the residue was diluted with water. The aqueous layer was washed with ether and then made weak acidic with 5 N hydrochloric acid. The aqueous layer was extracted with a THF-ethyl acetate mixed solvent, and then the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain the title compound (19 mg).
後処理
- customThe excess of methanol was evaporated under reduced pressure
- additionthe residue was diluted with water
- washThe aqueous layer was washed with ether
- extractionThe aqueous layer was extracted with a THF-ethyl acetate mixed solvent
- dry with materialthe organic layer was dried over anhydrous magnesium sulfate
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-0790f1e12d9b43d5997abaf23c789731
- 出典データセット
- uspto-grants-2012_04
- 特許番号
- US08158620B2
反応ノート
読み込み中…